Journal article
Myocardial fibrosis and arrhythmic burden in systemic sclerosis
L Ross, B Costello, Z Brown, D Hansen, A Lindqvist, W Stevens, A Burns, D Prior, M Nikpour, A La Gerche
Rheumatology United Kingdom | OXFORD UNIV PRESS | Published : 2022
Abstract
Objectives. Cardiac complications of SSc are a leading cause of SSc-associated death. Cardiac imaging for identifying substrate abnormality may be useful in predicting risk of cardiac arrhythmias or future cardiac failure. The aim of this study was to quantify the burden of asymptomatic fibro-inflammatory myocardial disease using cardiac magnetic resonance imaging (CMR) and assess the relationship between asymptomatic myocardial fibrosis and cardiac arrhythmias in SSc. Methods. Thirty-two patients with SSc with no documented history of pulmonary vascular or heart disease underwent CMR with gadolinium and 24-h ambulatory ECG. Focal myocardial fibrosis was assessed using post-gadolinium imagin..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
This work was supported by a National Heart Foundation of Australia Vanguard Grant [102206], Arthritis Australia-Australian Rheumatology Association Project Grant, Scleroderma Victoria Project Grant, St Vincent's Hospital Research Endowment Fund Project Grant [88371], The University of Melbourne Research Establishment Grant, MSK Australia PhD Scholarship and an Australian Government Research Training Program Scholarship to L.R., the University of Melbourne Research Training Scholarship to Z.B., National Health and Medical Research Council of Australia Investigator Grant [GNT 1176538] to M.N. and the Australian National Heart Foundation Future Leader Fellowship [102021] to A.L.G.